sterol biosynthesis — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T20237	Fenhexamid	Elevate,Teldor	Antifungal
	Fenhexamid (Elevate), a sterol biosynthesis inhibitor, shows antifungal activity against the plant pathogenic fungus. Fenhexamid is used for agriculture and is present in measurable amounts in fruits and vegetables.		Antifungal
T20691	Fenpropidin	Ro12-3049,Ro-12-3049,Ro 12-3049	Antifungal
	Fenpropidin (Ro-12-3049), a fungicide, is a specific inhibitor of sterol 14-reductase and biosynthesis.		Antifungal
T0506	Clotrimazole	BAY b 5097,FB 5097	Antibacterial , Antibiotic , Antifection , Autophagy , Antifungal
	Clotrimazole (FB 5097), an imidazole derivative with a broad spectrum of antimycotic activity, inhibits biosynthesis of the sterol ergostol.
T14362	AY 9944		Others
	AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM). At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomera...		Others
T21482	Uniconazole		P450 , ROS Kinase
	Uniconazole is a plant growth regulator that inhibit cytochrome P450 707As (Ki=68 nM). CYP707As is a major ABA catabolic enzyme that catabolize Abscisic acid, accordingly suppress gibberellin and sterol biosynthesis.		P450 , ROS Kinase
T1543	Naftifine hydrochloride	Naftifungin,Naftifine HCl,Naftin,Exoderil	Hedgehog/Smoothened , Antibiotic , Antifungal
	Naftifine Hydrochloride is the hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum antifungal activity. Although the exact mechanism through which naftifine hydrochloride exerts its...		Hedgehog/Smoothened , Antibiotic , Antifungal
T4717	25-Hydroxycholesterol		Others , Endogenous Metabolite , HMG-CoA Reductase
	25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs). It inhibits HMG-CoA reductase and so it also plays a significant role in the in vivo regu...		Others , Endogenous Metabolite , HMG-CoA Reductase
T10910	Cycloartenol		Others
	Cyclopentanol is a plant sterol compound and one of the key precursors for biosynthesis of various sterol compounds. Cycloartenol inhibits the migration of glioma cells and inhibits the phosphorylation of p38 MAP kinase....		Others
T15708	Lanoconazole		Antifungal
	Lanoconazole is an orally active imidazole antifungal agent that displays a broad spectrum of activity against fungi in vitro and in vivo. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alph...		Antifungal
T73807	Geranyl diphosphate
	Geranyl diphosphate, a crucial intermediate in the isoprenoid biosynthesis pathway (IBP), significantly contributes to cellular metabolism by facilitating the production of sterol and non-sterol isoprenoids [1] [2].
T22559	Alendronate sodium		Others
	The compound binds and blocks farnesyl diphosphate synthase in the HMG-CoA pathway (IC50 = 460 nM for recombinant human FPPS). It causes macrophage apoptosis and inhibits prenylation and sterol biosynthesis in purified o...		Others
T9802	Penconazole
	Penconazole is a typical triazole fungicide, which mainly used to control powdery mildew in apples, grapes, and vegetables. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cer...
T68219	Peraclopone
	Peraclopone is a hypolidemic drug. It is an inhibitor of 7-Dehydrocholesterol reductase. Peraclopone potently inhibits the final step in cholesterol biosynthesis. Feeding this agent to rats leads to a rapid replacement o...
T37322	Steryl Glucosides
	Steryl glucosides are neutral glycolipids commonly found in plant cell membranes and vegetable oils that contain a glucose moiety conjugated to a sterol lipid. They function as glucose donors in the biosynthesis of gluco...
T60853	(Z)-Lanoconazole
	(Z)-Lanoconazole is the Z configuration of Lanoconazole which used for dermatophytosis and onychomycosis investigation. Lanoconazole inhibits sterol 14-alpha demethylase and blocks fungal membrane ergosterol biosynthesis...
T41322	Dimethomorph
	Dimethomorph is a morpholine fungicide belonging to the fungicide group of sterol biosynthesis inhibitors that inhibits fungal cell wall formation. Dimethomorph inhibits mycelial growth of the oomycete fungi, P. citropht...
T35665	Pregnanetriol
	Pregnanetriol is a metabolite of 17α-hydroxyprogesterone .1,2It is formed from 17α-hydroxyprogesterone by reduction of the C-20 ketone.2Urinary levels of pregnanetriol are elevated in patients with 21-hydroxylase deficie...